Yes, i agree with the side effects of taking Accutane (isotretinoin). I'm a pharmacist. Isotretinoin is usually prescribed to those who have severe acne problem. But, i would suggest that isotretinoin should be your last option. Me myself have been combating skin problem for years! And i go for botanical, natural products. Plus some herbal and organic supplement for skin. Thank God, my skin improves a lot.